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Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

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Abstract

Silver (Ag(I)) binding to consensus zinc fingers (ZFs) causes Zn(II) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(I)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

Graphical abstract: Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

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Article information


Submitted
04 Dec 2019
Accepted
19 Dec 2019
First published
08 Jan 2020

This article is Open Access

Chem. Commun., 2020, Advance Article
Article type
Communication

Formation of highly stable multinuclear AgnSn clusters in zinc fingers disrupts their structure and function

K. Kluska, M. D. Peris-Díaz, D. Płonka, A. Moysa, M. Dadlez, A. Deniaud, W. Bal and A. Krężel, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09418K

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