Jump to main content
Jump to site search

Issue 15, 2020
Previous Article Next Article

Total degradation of extracellular amyloids by miniature artificial proteases

Author affiliations

Abstract

A miniaturized mimic of the active site of a protease, chymotrypsin, was linked to a target recognition unit to generate “Miniature Artificial Proteases” (mAPs). Time-resolved MALDI-TOF data analyses indicated that mAPs cleaved every amide bond between Lys16–Phe20 of the amyloid β fragment (Aβ12–21) and Aβ1–40, resulting in inhibition of fibrillization and disruption of the preformed amyloid. Such a platform may offer not only new therapeutic options against various amyloidoses but also novel routes for the selective knockdown of specific proteins.

Graphical abstract: Total degradation of extracellular amyloids by miniature artificial proteases

Back to tab navigation

Supplementary files

Article information


Submitted
04 Dec 2019
Accepted
19 Jan 2020
First published
20 Jan 2020

Chem. Commun., 2020,56, 2348-2351
Article type
Communication

Total degradation of extracellular amyloids by miniature artificial proteases

T. Mondal and B. Mandal, Chem. Commun., 2020, 56, 2348
DOI: 10.1039/C9CC09409A

Social activity

Search articles by author

Spotlight

Advertisements