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A phosphoryl radical-initiated Atherton–Todd-type reaction under open air

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Abstract

A phosphoryl radical-initiated Atherton–Todd-type reaction using air as the radical initiator and CHCl3 as the halogenating reagent for the phosphorylation of alcohols, phenols, and amines has been developed. This novel transformation provides a highly efficient route to important phosphinates, phosphinic amides, and phosphoramidates in up to 99% yield with a broad substrate scope under very mild conditions (48 examples).

Graphical abstract: A phosphoryl radical-initiated Atherton–Todd-type reaction under open air

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Article information


Submitted
04 Dec 2019
Accepted
20 Dec 2019
First published
20 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

A phosphoryl radical-initiated Atherton–Todd-type reaction under open air

Y. Ou, Y. Huang, Z. He, G. Yu, Y. Huo, X. Li, Y. Gao and Q. Chen, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09407E

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