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Issue 6, 2020
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BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis

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Abstract

Endowing BODIPY PDT agents with the ability to probe lipid droplets is demonstrated to boost their phototoxicity, allowing the efficient use of highly fluorescent dyes (poor ROS sensitizers) as phototoxic agents. Conversely, this fact opens the way to the development of highly bright ROS photosensitizers for performing photodynamic theragnosis (fluorescence bioimaging and photodynamic therapy) from a single simple agent. On the other hand, the noticeable capability of some of the reported dyes to probe lipid droplets in different cell lines under different conditions reveals their use as privileged probes for advancing the study of interesting lipid droplets by fluorescence microscopy.

Graphical abstract: BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis

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Supplementary files

Article information


Submitted
03 Dec 2019
Accepted
11 Dec 2019
First published
11 Dec 2019

Chem. Commun., 2020,56, 940-943
Article type
Communication

BODIPYs revealing lipid droplets as valuable targets for photodynamic theragnosis

A. Tabero, F. García-Garrido, A. Prieto-Castañeda, E. Palao, A. R. Agarrabeitia, I. García-Moreno, A. Villanueva, S. de la Moya and M. J. Ortiz, Chem. Commun., 2020, 56, 940
DOI: 10.1039/C9CC09397D

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