Switching enzyme activity by a temperature responsive inhibitor modified polymer

Falko O. Rottke; Marie-Victoria Heyne; Stefan Reinicke

doi:10.1039/C9CC09385K

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Switching enzyme activity by a temperature responsive inhibitor modified polymer†

Falko O. Rottke,

^ab Marie-Victoria Heyne^a and Stefan Reinicke

*^a

Author affiliations

* Corresponding authors

^a Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, 14476 Potsdam, Germany
E-mail: Stefan.Reinicke@iap.fraunhofer.de

^b Chair of Polymer Materials and Polymer Technologies, University of Potsdam, Institute of Chemistry, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany

Abstract

A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer–inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.

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Article information

DOI: https://doi.org/10.1039/C9CC09385K
Article type: Communication
Submitted: 03 Dec 2019
Accepted: 21 Jan 2020
First published: 22 Jan 2020

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Chem. Commun., 2020,56, 2459-2462

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Switching enzyme activity by a temperature responsive inhibitor modified polymer

F. O. Rottke, M. Heyne and S. Reinicke, Chem. Commun., 2020, 56, 2459 DOI: 10.1039/C9CC09385K

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Chemical Communications

Switching enzyme activity by a temperature responsive inhibitor modified polymer†

Abstract

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Switching enzyme activity by a temperature responsive inhibitor modified polymer

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