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Switching enzyme activity by a temperature responsive inhibitor modified polymer

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Abstract

A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer–inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.

Graphical abstract: Switching enzyme activity by a temperature responsive inhibitor modified polymer

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Article information


Submitted
03 Dec 2019
Accepted
21 Jan 2020
First published
22 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Switching enzyme activity by a temperature responsive inhibitor modified polymer

F. O. Rottke, M. Heyne and S. Reinicke, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09385K

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