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Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

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Abstract

We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3  ×  10−13 g mL−1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.

Graphical abstract: Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

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Article information


Submitted
03 Dec 2019
Accepted
31 Jan 2020
First published
01 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

X. Zhang, D. Xu, D. Guo, H. Han, D. Li and W. Ma, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09379F

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