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Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system

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Abstract

Reductive amidation of alkyl tosylates with isocyanates using the Ni/Co-dual catalytic system is disclosed. The method proceeds efficiently under mild conditions, giving rise to the corresponding alkyl amides. Notably, the protocol can discriminate the steric environment of two alkyl tosylate moieties, enabling regioselective mono-amidation at the less-bulky site.

Graphical abstract: Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system

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Article information


Submitted
03 Dec 2019
Accepted
20 Dec 2019
First published
20 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Reductive amidation of alkyl tosylates with isocyanates by a Ni/Co-dual catalytic system

T. Michiyuki, I. Osaka and K. Komeyama, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09377J

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