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Issue 5, 2020
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Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

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Abstract

A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal–organic framework (MOF), a biscyclometalated iridium(III) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.

Graphical abstract: Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

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Article information


Submitted
02 Dec 2019
Accepted
09 Dec 2019
First published
09 Dec 2019

Chem. Commun., 2020,56, 762-765
Article type
Communication

Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Y. Zhang, H. Fu, S. Chen, B. Liu, W. Sun and H. Gao, Chem. Commun., 2020, 56, 762
DOI: 10.1039/C9CC09357E

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