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Abstract | Cited by

A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal–organic framework (MOF), a biscyclometalated iridium(III) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.

Graphical abstract: Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

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