Issue 5, 2020

Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Abstract

A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal–organic framework (MOF), a biscyclometalated iridium(III) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.

Graphical abstract: Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2019
Accepted
09 Dec 2019
First published
09 Dec 2019

Chem. Commun., 2020,56, 762-765

Construction of an iridium(III)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging

Y. Zhang, H. Fu, S. Chen, B. Liu, W. Sun and H. Gao, Chem. Commun., 2020, 56, 762 DOI: 10.1039/C9CC09357E

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