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Issue 12, 2020
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SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

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Abstract

Herein, we disclose the first set of unique selenium-containing SnAP reagents for the direct synthesis of C-substituted selenomorpholines and 1,4-selenazepanes, including their amino acid derivatives from commercially available aldehydes under mild conditions. These elusive N-unprotected heterocycles are not accessible by classical routes. Biological evaluation of these compounds revealed promising activities against clinically relevant fungal strains.

Graphical abstract: SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

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Article information


Submitted
30 Nov 2019
Accepted
06 Jan 2020
First published
06 Jan 2020

Chem. Commun., 2020,56, 1780-1783
Article type
Communication

SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

G. Zhou, X. Deng, J. Tian, M. H. U. T. Fazil, R. Lakshminarayanan and R. Srinivasan, Chem. Commun., 2020, 56, 1780
DOI: 10.1039/C9CC09337K

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