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SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

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Abstract

Herein, we disclose the first set of unique selenium-containing SnAP reagents for the direct synthesis of C-substituted selenomorpholines and 1,4-selenazepanes, including their amino acid derivatives from commercially available aldehydes under mild conditions. These elusive N-unprotected heterocycles are not accessible by classical routes. Biological evaluation of these compounds revealed promising activities against clinically relevant fungal strains.

Graphical abstract: SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

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Article information


Submitted
30 Nov 2019
Accepted
06 Jan 2020
First published
06 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

SnAP reagents for the synthesis of selenomorpholines and 1,4-selenazepanes and their biological evaluation

G. Zhou, X. Deng, J. Tian, M. H. U. T. Fazil, R. Lakshminarayanan and R. Srinivasan, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09337K

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