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Issue 10, 2020
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Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

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Abstract

This review discusses the advantages of using luminescent d6-transition-metal complexes as cell probes for optical microscopy. In particular it focusses on the Thomas group's use of specific complexes as “building blocks” toward the construction of biomolecular binding substrates, with DNA being a particular target. Using this approach, a range of new imaging probes for conventional optical microscopy, nanoscopy and transmission electron microscopy have been identified. Through selection of specific metal centres and by substitution of coordinated ligands we illustrate how new chemotherapeutics, photo-therapeutics, and theranostics have been identified and developed from the original architectures.

Graphical abstract: Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

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Article information


Submitted
29 Nov 2019
Accepted
10 Jan 2020
First published
10 Jan 2020

Chem. Commun., 2020,56, 1464-1480
Article type
Feature Article

Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics

H. K. Saeed, S. Sreedharan and J. A. Thomas, Chem. Commun., 2020, 56, 1464
DOI: 10.1039/C9CC09312E

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