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An oxidatively damaged G-quadruplex/hemin DNAzyme

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Abstract

Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower hemin affinity and a modification of the nature of hemin binding sites.

Graphical abstract: An oxidatively damaged G-quadruplex/hemin DNAzyme

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Article information


Submitted
27 Nov 2019
Accepted
06 Jan 2020
First published
07 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An oxidatively damaged G-quadruplex/hemin DNAzyme

J. Wang, M. Cheng, J. Chen, H. Ju, D. Monchaud, J. Mergny and J. Zhou, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09237D

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