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A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

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Abstract

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.

Graphical abstract: A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

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Article information


Submitted
27 Nov 2019
Accepted
09 Jan 2020
First published
09 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

G. Lv, A. Sun, M. Wang, P. Wei, R. Li and T. Yi, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09233A

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