Issue 11, 2020
From the journal:

Chemical Communications

A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease†

Guanglei Lv,ab   Anyang Sun,*c   Minqi Wang,c   Peng Wei,a   Ruohan Lia  and  Tao Yi ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Fudan University, Shanghai 200438, P. R. China
E-mail: yitao@fudan.edu.cn

b Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua 321004, P. R. China

c Laboratory of Neurodegenerative Diseases and Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China
E-mail: sunay@sumhs.edu.cn

Abstract

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.

Graphical abstract: A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C9CC09233A
Article type
Communication
Submitted
27 Nov 2019
Accepted
09 Jan 2020
First published
09 Jan 2020

Chem. Commun., 2020,56, 1625-1628

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A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease

G. Lv, A. Sun, M. Wang, P. Wei, R. Li and T. Yi, Chem. Commun., 2020, 56, 1625 DOI: 10.1039/C9CC09233A

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