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Issue 15, 2020
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Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms

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Abstract

Carbon quantum dots derived from gentamicin sulfate are directly developed by facile calcination at different temperatures. A promising nanomaterial, CQD180, even shows a much superior antibacterial activity compared with the antibiotic counterpart and low drug resistance, by preserving the active structure of the starting materials and providing an additional antibacterial mode arising from the positive charge surface and induced reactive oxygen species simultaneously. Moreover, CQD180 can effectively disrupt mature Staphylococcus aureus biofilm and selectively eliminate bacteria over mammalian cells.

Graphical abstract: Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms

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Article information


Submitted
27 Nov 2019
Accepted
14 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020,56, 2316-2319
Article type
Communication

Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms

P. Li, S. Liu, W. Cao, G. Zhang, X. Yang, X. Gong and X. Xing, Chem. Commun., 2020, 56, 2316
DOI: 10.1039/C9CC09223D

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