Jump to main content
Jump to site search


Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2

Author affiliations

Abstract

The pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5,7,7] ring system featuring an α-methylene-γ-lactone moiety, together with a new pseudoguaianelactone C (3) were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited nitric oxide (NO) production, with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds significantly suppressed the production of pro-inflammatory mediators (TNF-α, IL-6, IL-1β and PGE2) and the protein expression of the enzymes iNOS and COX-2.

Graphical abstract: Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2

Back to tab navigation

Supplementary files

Article information


Submitted
25 Nov 2019
Accepted
20 Dec 2019
First published
27 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Pseudoguaianelactones A–C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2

Q. Ruan, S. Jiang, X. Zheng, Y. Tang, B. Yang, T. Yi, J. Jin, H. Cui and Z. Zhao, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09159A

Social activity

Search articles by author

Spotlight

Advertisements