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Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

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Abstract

We herein develop two β-galactosidase (β-Gal) activatable NIR fluorescent probes for visualizing ovarian cancers. Particularly, probe BOD-M-βGal produced NIR-II emission light at 900–1300 nm upon β-Gal activation. By using our activatable and target specific NIR-II probe for deep-tissue imaging of β-Gal overexpressed ovarian cancer cells, rapid and accurate imaging of ovarian tumors in nude mice was achieved.

Graphical abstract: Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

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Article information


Submitted
25 Nov 2019
Accepted
28 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Imaging of ovarian cancers using enzyme activatable probes with second near-infrared window emission

J. Chen, H. Pan, Z. Wang, J. Gao, J. Tan, Z. Ouyang, W. Guo and X. Gu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09158K

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