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Homogeneous and universal transduction of various nucleic acids to an off-shelf device based on programmable toehold switch sensing

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Abstract

Through a rational construction of an RNA toehold switch sensor, the glucometer-based detection of nucleic acids was innovatively simplified into a completely homogeneous and label-free process. Compared with traditional strategies that rely on multiple operations such as chemical conjugation and bead separation, this new strategy is more robust, user-friendly, reagent-saving, and reproducible, and can be universally adapted for use on extensive target species, e.g. herein, the real-world pathogen genes.

Graphical abstract: Homogeneous and universal transduction of various nucleic acids to an off-shelf device based on programmable toehold switch sensing

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Article information


Submitted
25 Nov 2019
Accepted
13 Jan 2020
First published
13 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Homogeneous and universal transduction of various nucleic acids to an off-shelf device based on programmable toehold switch sensing

Y. Tang, H. Li and B. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09154H

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