Jump to main content
Jump to site search


Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

Author affiliations

Abstract

Here we demonstrated that the stiffness of cationized gelatin nanoparticles determined the efficiency of RNAi in myeloid leukemia cells when the particle size and surface charges were kept constant. The siRNA delivery system with an elastic modulus of 0.87 MPa showed the largest siRNA uptake and RNAi efficiency for hard-to-transfect suspension cells.

Graphical abstract: Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

Back to tab navigation

Supplementary files

Article information


Submitted
21 Nov 2019
Accepted
18 Dec 2019
First published
18 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

W. Zhang, B. Han, X. Lai, C. Xiao, S. Xu, X. Meng, Z. Li, J. Meng, T. Wen, X. Yang, J. Liu and H. Xu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09068A

Social activity

Search articles by author

Spotlight

Advertisements