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A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly

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Abstract

This article presents a new label-free fluorescence assay based on supramolecular self-assembly of cucurbit[7]uril and specific peptide Gly-Pro-Phe-Gly for monitoring DPP4 activity in clinical samples. It also displays a good potential application in high-throughput screening of DPP4 inhibitors.

Graphical abstract: A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly

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Article information


Submitted
21 Nov 2019
Accepted
06 Jan 2020
First published
07 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly

Y. Zhao, J. Zou, Y. Song, J. Peng, Y. Wang and Y. Bi, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09053C

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