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Highly regioselective ring-opening of epoxides with amines: a metal- and solvent-free protocol for the synthesis of β-amino alcohols

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Abstract

We herein report a metal- and solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.

Graphical abstract: Highly regioselective ring-opening of epoxides with amines: a metal- and solvent-free protocol for the synthesis of β-amino alcohols

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Article information


Submitted
20 Nov 2019
Accepted
17 Jan 2020
First published
17 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Highly regioselective ring-opening of epoxides with amines: a metal- and solvent-free protocol for the synthesis of β-amino alcohols

D. Li, J. Wang, S. Yu, S. Ye, W. Zou, H. Zhang and J. Chen, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09048G

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