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A self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells

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Abstract

Based on the structural programmability and spatial addressability of DNA nanodevices, a target-triggered, enzyme-free 3D DNA walker, comprising of hairpin DNA assembled gold nanoparticles with a local catalytic hairpin assembly reaction, was developed for the highly sensitive detection of intracellular tumor-associated microRNAs.

Graphical abstract: A self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells

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Article information


Submitted
20 Nov 2019
Accepted
14 Jan 2020
First published
14 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A self-powered 3D DNA walker with programmability and signal-amplification for illuminating microRNA in living cells

X. Yang, M. Cui, X. Li, H. Chen and J. Xu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09039H

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