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Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

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Abstract

We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous detection of multiple posttranslational modification (PTM) enzymes with a detection limit of 28 pM for histone deacetylase (HDAC) and 0.8 pM for protein tyrosine phosphatase 1B (PTP1B), and it can be further applied for the screening of PTM enzyme inhibitors and the measurement of PTM enzymes in cancer cells.

Graphical abstract: Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

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Publication details

The article was received on 19 Nov 2019, accepted on 29 Nov 2019 and first published on 29 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC09019C
Chem. Commun., 2020, Advance Article

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    Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes

    D. Zhang, Y. Meng and C. Zhang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC09019C

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