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Issue 24, 2020
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Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

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Abstract

Nanoparticle tracers with small sizes and large magnetization are critical for biomedical imaging and especially for magnetic particle imaging (MPI). Small size is important for accessing future intracellular and neurological in vivo applications Here, we show <15 nm nanoparticles made of zero valent iron cores, iron oxide shells and coated with a strongly binding brush co-polymer are effective MPI tracers. The small nanoparticle cores create a hydrodynamic diameter that is half of the state-of-the-art iron oxide tracers while the strongly magnetic zero valent iron maintains similar MPI signal magnitude and resolution.

Graphical abstract: Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

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Supplementary files

Article information


Submitted
18 Nov 2019
Accepted
16 Feb 2020
First published
26 Feb 2020

Chem. Commun., 2020,56, 3504-3507
Article type
Communication

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

L. Gloag, M. Mehdipour, M. Ulanova, K. Mariandry, M. A. Nichol, D. J. Hernández-Castillo, J. Gaudet, R. Qiao, J. Zhang, M. Nelson, B. Thierry, M. A. Alvarez-Lemus, T. T. Tan, J. J. Gooding, N. Braidy, P. S. Sachdev and R. D. Tilley, Chem. Commun., 2020, 56, 3504
DOI: 10.1039/C9CC08972A

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