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Issue 10, 2020
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Gallium(iii)-polypyridyl complexes as anti-osteosarcoma stem cell agents

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Abstract

Gallium(III) complexes with polypridyl ligands are shown to kill bulk osteosarcoma cells and osteosarcoma stem cells (OSCs) with up to nanomolar potency. The most effective complex induces apoptosis in osteosarcoma cells by damaging genomic DNA. To the best of our knowledge this is the first investigation into metal-based anti-OSC agents.

Graphical abstract: Gallium(iii)-polypyridyl complexes as anti-osteosarcoma stem cell agents

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Supplementary files

Article information


Submitted
18 Nov 2019
Accepted
26 Dec 2019
First published
27 Dec 2019

Chem. Commun., 2020,56, 1509-1512
Article type
Communication

Gallium(III)-polypyridyl complexes as anti-osteosarcoma stem cell agents

P. Robin, K. Singh and K. Suntharalingam, Chem. Commun., 2020, 56, 1509
DOI: 10.1039/C9CC08962D

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