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Construction of trifluoromethylated quaternary stereocenters via p-quinone methides

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Abstract

Development of a new synthetic method for the construction of quaternary centers with a trifluoromethyl group was realized by way of 1,6-addition of various nucleophiles including active methylene compounds to highly reactive δ-trifluoromethylated p-quinone methides generated in situ from the corresponding tertiary carbonates with a catalytic amount of an appropriate base.

Graphical abstract: Construction of trifluoromethylated quaternary stereocenters via p-quinone methides

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Article information


Submitted
15 Nov 2019
Accepted
03 Feb 2020
First published
04 Feb 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Construction of trifluoromethylated quaternary stereocenters via p-quinone methides

K. Terashima, T. Kawasaki-Takasuka, T. Agou, T. Kubota and T. Yamazaki, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08936E

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