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Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes

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Abstract

Asymmetric conjugate addition of PhMe2SiBPin to a wide range of N-heteroaryl alkenes proceeded in the presence of a copper catalyst coordinated with an easily accessible chiral phosphoramidite ligand to afford useful β-silyl N-heteroarenes in high yields (up to 96%) and excellent enantioselectivities (up to 97% ee).

Graphical abstract: Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes

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Article information


Submitted
14 Nov 2019
Accepted
06 Jan 2020
First published
06 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Copper-catalyzed asymmetric silyl addition to alkenyl-substituted N-heteroarenes

Y. Zeng, B. Chen, Y. Wang, C. He, Z. Mu, J. Du, L. He, W. Chu and Q. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08910A

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