Issue 5, 2020

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Abstract

Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

Graphical abstract: Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
14 Nov 2019
Accepted
10 Dec 2019
First published
18 Dec 2019

Chem. Commun., 2020,56, 822-825

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Z. J. Low, J. Xiong, Y. Xie, G. Ma, H. Saw, H. Thi Tran, S. L. Wong, L. M. Pang, J. Fong, P. Lu, J. Hu, Y. Liang, Y. Miao and Z. Liang, Chem. Commun., 2020, 56, 822 DOI: 10.1039/C9CC08908J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements