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Issue 5, 2020
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Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

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Abstract

Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

Graphical abstract: Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

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Article information


Submitted
14 Nov 2019
Accepted
10 Dec 2019
First published
18 Dec 2019

Chem. Commun., 2020,56, 822-825
Article type
Communication

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Z. J. Low, J. Xiong, Y. Xie, G. Ma, H. Saw, H. Thi Tran, S. L. Wong, L. M. Pang, J. Fong, P. Lu, J. Hu, Y. Liang, Y. Miao and Z. Liang, Chem. Commun., 2020, 56, 822
DOI: 10.1039/C9CC08908J

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