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Rh(iii)-catalyzed, hydrazine-directed C–H functionalization with 1-alkynylcyclobutanols: a new strategy for 1H-indazoles

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Abstract

Rh(III)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C–H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp–Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions.

Graphical abstract: Rh(iii)-catalyzed, hydrazine-directed C–H functionalization with 1-alkynylcyclobutanols: a new strategy for 1H-indazoles

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Article information


Submitted
15 Nov 2019
Accepted
27 May 2020
First published
27 May 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Rh(III)-catalyzed, hydrazine-directed C–H functionalization with 1-alkynylcyclobutanols: a new strategy for 1H-indazoles

L. Zhang, J. Chen, X. Chen, X. Zheng, J. Zhou, T. Zhong, Z. Chen, Y. Yang, X. Jiang, Y. She and C. Yu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08884A

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