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Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly

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Abstract

Herein, polymerization-induced electrostatic self-assembly (PIESA) is conducted to mediate the self-assembly behavior of short interfering RNA (siRNA) for the first time. In PIESA, siRNA not only formed a simple electrostatic polyplex with positively charged polycations, but also facilitated directed self-assembly due to the molecular rigidity of siRNA, leading to appealing nanotubes.

Graphical abstract: Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly

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Article information


Submitted
13 Nov 2019
Accepted
16 Jan 2020
First published
17 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly

L. Shen, Y. Li, Q. Lu, X. Qi, X. Wu, Z. Zhou and J. Shen, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08858J

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