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A stimuli-responsive anticancer drug delivery system with inherent antibacterial activities

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Abstract

We describe a novel class of stimuli-sensitive sulfonium-based synthetic lipids, which exhibit several favorable biophysical properties of phospholipids. The potent sulfonium-based lipid was successfully disassembled by glutathione to release the encapsulated drug molecules in a controlled manner. The cationic lipid also showed lower cytotoxicity against mammalian cells and displayed moderate antibacterial activities.

Graphical abstract: A stimuli-responsive anticancer drug delivery system with inherent antibacterial activities

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Article information


Submitted
12 Nov 2019
Accepted
08 Jan 2020
First published
08 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A stimuli-responsive anticancer drug delivery system with inherent antibacterial activities

S. Dey, A. Patel, K. Raina, N. Pradhan, O. Biswas, R. P. Thummer and D. Manna, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08834B

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