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Fluorescent nanosensor for in situ detection of phosphate and alkaline phosphatase in mice with parathyroid dysfunction

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Abstract

A composite nanosensor based on Zr(IV)-MOFs and PNPP was developed, and was successfully applied for the in situ fluorescence imaging of phosphate and ALP levels in mice with parathyroid dysfunction. The current work provides new ideas for further development of the diagnosis of parathyroid diseases.

Graphical abstract: Fluorescent nanosensor for in situ detection of phosphate and alkaline phosphatase in mice with parathyroid dysfunction

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Article information


Submitted
12 Nov 2019
Accepted
06 Jan 2020
First published
10 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Fluorescent nanosensor for in situ detection of phosphate and alkaline phosphatase in mice with parathyroid dysfunction

J. Xu, H. Zhang, W. Zhang, P. Li, W. Zhang, H. Wang and B. Tang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08828H

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