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A 'light-up’ intercalator displacement assay for detection of triplex DNA stabilizers

Abstract

Here, we developed a coralyne-based, 'light-up' intercalator displacement assay to identify molecular stabilizers of triplex DNA using a sequence from a chromosomal breakpoint hotspot in the human c-MYC oncogene. Its potential to identify triplex DNA ligands was demonstrated using BePI and doxorubicin. Identification of triplex-interacting ligands may allow the regulation of genetic instability in human genomes.

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Article information


Submitted
11 Nov 2019
Accepted
13 Jan 2020
First published
14 Jan 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

A 'light-up’ intercalator displacement assay for detection of triplex DNA stabilizers

I. M.A. del Mundo, E. Cho, K. N. Dalby and K. M. Vasquez, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/C9CC08817B

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