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NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

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Abstract

NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, suggesting that Sp1 could be the anti-metastasis target of NAMI-A.

Graphical abstract: NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

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Article information


Submitted
10 Nov 2019
Accepted
24 Dec 2019
First published
24 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

S. Yuan, S. Chen, H. Wu, H. Jiang, S. Zheng, Q. Zhang and Y. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08775C

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