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Iridium-catalyzed, ligand-controlled directed alkynylation and alkenylation of arenes with terminal alkynes

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Abstract

We report iridium-catalyzed C–C formation between benzamides and terminal alkynes. With the choice of a suitable ligand, a C–H alkynylation or alkenylation product could be obtained selectively. The directed C–H alkynylation proceeded without the need for an external oxidant, while the directed C–H alkenylation likely involves an unusual vinylidene mechanism. This divergent reactivity provides access to both alkynylation and alkenylation products from the same set of starting materials.

Graphical abstract: Iridium-catalyzed, ligand-controlled directed alkynylation and alkenylation of arenes with terminal alkynes

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Article information


Submitted
08 Nov 2019
Accepted
19 Dec 2019
First published
19 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Iridium-catalyzed, ligand-controlled directed alkynylation and alkenylation of arenes with terminal alkynes

X. Sun, W. Zhao and B. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08735D

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