Jump to main content
Jump to site search


Solvent-controlled divergent annulation of ynones and (iso)quinoline N-oxides: of 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones

Author affiliations

Abstract

An effective annulation of ynones and (iso)quinoline N-oxides was developed to deliver various functionalized 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones in moderate to excellent yields, respectively. This protocol exhibits high regioselectivity and broad substrate scope under transition-metal-free conditions. Moreover, the key reaction intermediate was successfully isolated and determined unambiguously by single crystal X-ray crystallography.

Graphical abstract: Solvent-controlled divergent annulation of ynones and (iso)quinoline N-oxides: of 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones

Back to tab navigation

Supplementary files

Article information


Submitted
07 Nov 2019
Accepted
16 Dec 2019
First published
16 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Solvent-controlled divergent annulation of ynones and (iso)quinoline N-oxides: of 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones

W. Yang, L. Chen, P. Chen, Y. Ye, Y. Wang and X. Zhang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08713C

Social activity

Search articles by author

Spotlight

Advertisements