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Atom-economical design of PET tracer for imaging αvβ3 integrin via utilizing three-in-one function of 64Copper

Abstract

In this study, αvβ3 integrin in U87 tumor was imaged with a 64Cu-peptidic probe, in which linear peptide GHRGDHG is used as a pre-ligand, while 64Cu bears three functional roles that include generation of PET signal, coordination with two GHs moieties of the pre-ligand, and cyclizing the linear pre-ligand into an active cyclic-RGD form (termed as 64Cu-Cyclo-RGD) for αvβ3 integrin.

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Article information


Submitted
06 Nov 2019
Accepted
07 Jan 2020
First published
10 Jan 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Atom-economical design of PET tracer for imaging αvβ3 integrin via utilizing three-in-one function of 64Copper

J. Yang, J. Yang, H. Wang, J. Wang, J. Xiong, C. Qiao and C. Ran, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/C9CC08690K

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