Issue 11, 2020
From the journal:

Chemical Communications

Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity†

Qize Xuan,a   Jiaxin He,a   Min Li, ORCID logo b   Ruoshi Chai,a   Chenxuan Wang, ORCID logo *c   Yibing Wang ORCID logo *a  and  Ping Wangd  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Biomedical Nanotechnology Center, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China
E-mail: ybwang@ecust.edu.cn

b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, 19B Yuquan Road, Beijing 100049, Shijingshan District, China

c State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biophysics and Structural Biology, Peking Union Medical College, Beijing 100005, China
E-mail: wangcx@ibms.pumc.edu.cn

d Department of Bioproducts and Biosystems Engineering, University of Minnesota, St Paul, MN 55108, USA

Abstract

We utilized solution-phase biopanning to obtain a de novo peptide (LA12) that specifically bound to the core region of the human amylin monomer. LA12 stabilized the random coil conformation of amylin to suppress aggregation in a dose-dependent manner with the highest suppression effect of 78% and reduced the cytotoxicity of amylin.

Graphical abstract: Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC08671D
Article type
Communication
Submitted
06 Nov 2019
Accepted
07 Jan 2020
First published
08 Jan 2020

Chem. Commun., 2020,56, 1633-1636

Permissions

Request permissions

Monomer-targeting affinity peptide inhibitors of amyloid with no self-fibrillation and low cytotoxicity

Q. Xuan, J. He, M. Li, R. Chai, C. Wang, Y. Wang and P. Wang, Chem. Commun., 2020, 56, 1633 DOI: 10.1039/C9CC08671D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements