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Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

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Abstract

A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane–naphthalimide fluorescent camptothecin prodrug (AdaCPT) and β-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.

Graphical abstract: Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

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Article information


Submitted
31 Oct 2019
Accepted
13 Dec 2019
First published
16 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular imaging and in situ controlled drug release

Y. Zhang, Y. Zhang, X. Sheng, J. Wang and Y. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08491F

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