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The dual-catalyzed boryldifluoroallylation of alkynes: an efficient method for the synthesis of skipped gem-difluorodienes

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Abstract

The Cu/Pd-catalyzed boryldifluoroallylation of alkynes was achieved, providing the corresponding skipped gem-difluorodiene scaffolds with high regio- and stereoselectivity in moderate to excellent yields. This new approach has good functional group compatibility for both alkynes and 3,3-difluoro-substituted allylic esters. Moreover, an array of synthetic building blocks, skipped dienes, trienes, and drug mimics can be obtained via further transformations.

Graphical abstract: The dual-catalyzed boryldifluoroallylation of alkynes: an efficient method for the synthesis of skipped gem-difluorodienes

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Article information


Submitted
30 Oct 2019
Accepted
09 Jan 2020
First published
29 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

The dual-catalyzed boryldifluoroallylation of alkynes: an efficient method for the synthesis of skipped gem-difluorodienes

K. Zhuo, W. Xu, T. Gong and Y. Fu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08485A

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