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A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

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Abstract

Abnormal vitamin B6 status, marked by deficient intracellular concentrations of pyridoxal phosphate (PLP), is classified as a direct biomarker based on its biomedical significance. However, there exist no direct methods for measuring vitamin B6 status in intact cells. Here we describe the development of a fluorogenic probe, RAB6, which shows remarkable selectivity for PLP among the B6 vitamers and other cellular aldehydes.

Graphical abstract: A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

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Publication details

The article was received on 29 Oct 2019, accepted on 21 Nov 2019 and first published on 22 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC08458D
Chem. Commun., 2020, Advance Article

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    A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

    Y. W. Jun, M. Hebenbrock and E. T. Kool, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08458D

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