Jump to main content
Jump to site search

Issue 2, 2020
Previous Article Next Article

A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

Author affiliations

Abstract

Abnormal vitamin B6 status, marked by deficient intracellular concentrations of pyridoxal phosphate (PLP), is classified as a direct biomarker based on its biomedical significance. However, there exist no direct methods for measuring vitamin B6 status in intact cells. Here we describe the development of a fluorogenic probe, RAB6, which shows remarkable selectivity for PLP among the B6 vitamers and other cellular aldehydes.

Graphical abstract: A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

Back to tab navigation

Supplementary files

Article information


Submitted
29 Oct 2019
Accepted
21 Nov 2019
First published
22 Nov 2019

Chem. Commun., 2020,56, 317-320
Article type
Communication

A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status

Y. W. Jun, M. Hebenbrock and E. T. Kool, Chem. Commun., 2020, 56, 317
DOI: 10.1039/C9CC08458D

Social activity

Search articles by author

Spotlight

Advertisements