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Adenosine triphosphate responsive metal–organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor

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Abstract

A novel ratiometric surface-enhanced Raman scattering (SERS) biosensor was constructed based on stimuli-responsive DNA functionalized metal organic frameworks (MOFs) for detection of adenosine triphosphate (ATP). As a result, the detection range of ATP was 1 nM to 200 nM with a detection limit of 0.4 nM. The ratiometric SERS biosensor strategy offers a lower detection limit and exhibits a more enhanced performance than the typical SERS detection based on single signal response, which may have potential for detection of other biomolecules or metal ions.

Graphical abstract: Adenosine triphosphate responsive metal–organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor

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Article information


Submitted
29 Oct 2019
Accepted
23 Dec 2019
First published
24 Dec 2019

Chem. Commun., 2020, Advance Article
Article type
Communication

Adenosine triphosphate responsive metal–organic frameworks equipped with a DNA structure lock for construction of a ratiometric SERS biosensor

C. Wu, S. Wang, X. Luo, R. Yuan and X. Yang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08440A

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