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Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

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Abstract

The first proteolysis targeting chimeras for the intracellular elimination of transforming growth factor-β1 (TGF-β1), which contributes to various diseases, are described. The appropriately designed DT-6 could efficiently degrade intracellular TGF-β1, and inhibit M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells.

Graphical abstract: Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

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Article information


Submitted
26 Oct 2019
Accepted
30 Jan 2020
First published
31 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events

Y. Feng, H. Su, Y. Li, C. Luo, H. Xu, Y. Wang, H. Sun, G. Wan, B. Zhou and X. Bu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08391J

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