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Issue 1, 2020
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Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

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Abstract

A kind of light-responsive vesicle was prepared by aqueous self-assembly of α-CD and an azobenzene-containing M-helical foldamer, which displayed dynamic disassembly–reassembly structural transformation when alternately irradiated by UV and visible light. Distinctively, this vesicle also exhibited enantioselective release abilities toward racemic propranolol (a β-blocker), owing to the M-helical building blocks.

Graphical abstract: Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

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Submitted
26 Oct 2019
Accepted
25 Nov 2019
First published
28 Nov 2019

Chem. Commun., 2020,56, 149-152
Article type
Communication

Light-responsive vesicles for enantioselective release of chiral drugs prepared from a supra-amphiphilic M-helix

T. Yan, F. Li, S. Qi, J. Tian, R. Tian, J. Hou, Q. Luo, Z. Dong, J. Xu and J. Liu, Chem. Commun., 2020, 56, 149
DOI: 10.1039/C9CC08380D

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