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A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

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Abstract

A functionalized dumbbell probe (FDP) based amplification method, termed as a cascading exponential amplification DNA machine (CEA-DNA machine), has been developed to autonomously accumulate single G-quadruplexes (SGQs) and twin-G-quadruplexes (TGQs) for robust fluorescence signal-on probing of miRNA-21.

Graphical abstract: A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

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Article information


Submitted
22 Oct 2019
Accepted
06 Jan 2020
First published
06 Jan 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

J. Wang, S. Li, J. Xu, Y. Lu, M. Lin, C. Wang, C. Zhang, G. Lin and L. Jia, Chem. Commun., 2020, Advance Article , DOI: 10.1039/C9CC08289A

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