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Issue 6, 2020
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Reversible detection of phosphorylation and dephosphorylation by tip-enhanced Raman spectroscopy using a cyclopentadienyl ruthenium nanotag functionalized tip

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Abstract

The detection of cancer invasion is crucial for diagnosis. In this report, we employed a TERS tip and SERS nanotags to create a cell signaling based nano-sensing system. This system is capable of creating a reversible phosphorylation/de-phosphorylation cycle for TERS measurement. The reversible TERS sensing is then paired with a downstream binding domain, Src homology region 2 (SH2), which is associated with the cell signaling for cancer cell invasion. Such a system offers the advantages of convenient detection of nanotags and high sensitivity as validated in a cell model.

Graphical abstract: Reversible detection of phosphorylation and dephosphorylation by tip-enhanced Raman spectroscopy using a cyclopentadienyl ruthenium nanotag functionalized tip

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Article information


Submitted
22 Oct 2019
Accepted
10 Dec 2019
First published
11 Dec 2019

Chem. Commun., 2020,56, 936-939
Article type
Communication

Reversible detection of phosphorylation and dephosphorylation by tip-enhanced Raman spectroscopy using a cyclopentadienyl ruthenium nanotag functionalized tip

Y. Lin, Z. Ke, P. Liao, C. Tseng and K. V. Kong, Chem. Commun., 2020, 56, 936
DOI: 10.1039/C9CC08269G

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