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Issue 5, 2020
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A novel naphthyridine tetramer that recognizes tandem G–G mismatches by the formation of an interhelical complex

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Abstract

We have designed and synthesized a novel naphthyridine tetramer, p-NCTB, for the recognition of tandem guanine–guanine (G–G) mismatches in DNA. p-NCTB possesses a p-biphenyl linker connecting two naphthyridine carbamate dimer (NCD) moieties that recognize G–G mismatches. p-NCTB preferentially bound to tandem G–G mismatches in dCGGG/dCGGG over dCGG/dCGG. Two dCGGG/dCGGG sites were simultaneously recognized and were noncovalently cross-linked via the formation of inter- and intrastrand complexes with p-NCTB. The intrastrand binding was more favorable, which could allow p-NCTB to bind selectively to a sequence containing multiple dCGGG/dCGGG sites.

Graphical abstract: A novel naphthyridine tetramer that recognizes tandem G–G mismatches by the formation of an interhelical complex

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Article information


Submitted
16 Oct 2019
Accepted
07 Dec 2019
First published
09 Dec 2019

Chem. Commun., 2020,56, 754-757
Article type
Communication

A novel naphthyridine tetramer that recognizes tandem G–G mismatches by the formation of an interhelical complex

Y. Lu, C. Dohno and K. Nakatani, Chem. Commun., 2020, 56, 754
DOI: 10.1039/C9CC08111A

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