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Issue 3, 2020
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Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

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Abstract

A facile and scalable strategy for the quick library synthesis of linear-, hinged-, star-, and cyclic-polypeptides with broad-spectrum antimicrobial activity has been reported. The topologically nanoengineered polypeptides show superior antimicrobial activity against Gram-positive and Gram-negative bacteria and low toxicity, allowing screening of architectural polypeptides as mimics of host defense peptides for antimicrobials.

Graphical abstract: Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

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Article information


Submitted
15 Oct 2019
Accepted
03 Dec 2019
First published
04 Dec 2019

Chem. Commun., 2020,56, 356-359
Article type
Communication

Facile and scalable synthesis of topologically nanoengineered polypeptides with excellent antimicrobial activities

Y. Zhang, W. Song, S. Li, D. Kim, J. H. Kim, J. R. Kim and I. Kim, Chem. Commun., 2020, 56, 356
DOI: 10.1039/C9CC08095C

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